Essential Thrombocythemia Market Set for Significant Growth Across 7MM | DelveInsight

The essential thrombocythemia market is on a growth trajectory, driven by increasing diagnosis rates, aging population demographics, and emerging targeted therapies to address this rare blood disorder. Leading pharmaceutical companies like pharma&, PharmaEssentia, Merck Sharp and Dohme, MorphoSys, Step Pharma, AOP Orphan Pharmaceuticals AG, Incyte Corporation, Janssen Research & Development, and others are driving innovation, shaping the essential thrombocythemia market’s expansion through 2034.

DelveInsight’s “Essential Thrombocythemia – Market Insight, Epidemiology And Market Forecast – 2034“ report provides a comprehensive understanding of essential thrombocythemia, historical and forecasted epidemiology, as well as market trends across the 7MM. The United States dominated the market landscape with USD 250 million, followed by Japan in 2024. Among the EU4 and the UK, France and the United Kingdom account for the highest market share, while Germany recorded the highest diagnosed prevalent cases.

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Essential thrombocythemia is a chronic myeloproliferative neoplasm characterized by an increased number of platelets in the blood, most commonly diagnosed in women over the age of 50. The primary cause is overproduction of hematopoietic cells due to mutations in JAK2, CALR, or MPL genes, with JAK2 mutations responsible for 75% of cases. Essential thrombocythemia symptoms are often absent and detected through routine tests. When present, they include fatigue, vessel disturbances, or bleeding. The median survival among patients is approximately 20 years, extending to 33 years for those diagnosed before age 60. The most significant causes of morbidity and mortality are thrombosis, occurring in 20% of patients, and bleeding complications in 10% of the population.

The epidemiological analysis reveals that the total diagnosed cases of essential thrombocythemia in the US were approximately 160K in 2024, with the highest age-specific burden observed in patients over 60 years, followed by those in the 40-60 years age group. The total first-line treated cases in the U.S. reached 85K, highlighting the significant treatment needs within this patient population.

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The current essential thrombocytosis approach focuses on reducing thrombotic complications through antiplatelet therapy and cytoreduction. Aspirin is commonly recommended across all risk categories, while first-line treatment typically combines aspirin with cytoreductive therapies such as hydroxyurea, anagrelide, and interferon-alpha, which aim to reduce platelet counts and prevent complications. Additional medications, including busulfan, clopidogrel, and anticoagulants, may be prescribed based on individual patient needs and treatment response.

With limited treatment options in the thrombocythaemia myelofibrosis treatment market, new approvals are crucial to addressing patient needs. In August 2024, pharma& achieved a major breakthrough with the European Commission’s approval of a Type II variation for PEGASYS (peginterferon alfa-2a) as a monotherapy for adults with essential thrombocythemia. This represents a notable advancement as currently, there is only one drug specifically approved for ET treatment in Europe, with no FDA-approved therapies in the United States.

The pipeline for essential thrombocythemia therapies shows promising momentum, with several key candidates advancing through clinical trials. BESREMi (AOP Orphan Pharmaceuticals AG and PharmaEssentia), currently FDA-approved for polycythemia vera, is expected to pursue label expansion for ET by the end of 2025 after this drug showed positive topline results from their Phase 3 SURPASS-ET trial. Merck Sharp and Dohme’s Bomedemstat (MK-3543/IMG-7289), an investigational LSD1 inhibitor with Orphan Drug and Fast Track designations for ET, is in Phase III development. Novartis’s Pelabresib (CPI-0610) represents another promising candidate in earlier development stages.

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DelveInsight’s analysis indicates that among the emerging therapies, BESREMi (AOP Orphan Pharmaceuticals AG and PharmaEssentia) and Bomedemstat (Merck Sharp and Dohme) appear most likely to transform the essential thrombocythemia market landscape, with BESREMi expected to generate the highest revenue by 2034. These advancements indicate a positive trajectory for the essential thrombocythemia market, with increasing therapeutic options potentially improving patient outcomes and market growth in the coming decade.

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Essential Thrombocythemia (ET) Pipeline Insight

Essential thrombocythemia Pipeline Insight provides comprehensive insights about the Essential Thrombocythemia pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the Essential Thrombocythemia companies, including PharmaEssentia, Imago BioSciences, Novartis and Constellation Pharmaceuticals among others.

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DelveInsight is a leading market research and consulting firm specializing in disease-specific insights and therapeutic market analysis. Their reports integrate real-world data, clinical trial findings, and expert interviews to deliver comprehensive industry intelligence.

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