DelveInsight’s “Acute Bacterial Skin and Skin Structure Infections – Market Insight, Epidemiology and Market Forecast – 2034” report provides current treatment practices, emerging drugs, Acute Bacterial Skin and Skin Structure Infections market share of the individual therapies, current and forecasted Acute Bacterial Skin and Skin Structure Infections market size from 2020 to 2034 segmented by seven major markets. The report also offers current Acute Bacterial Skin and Skin Structure Infections therapy algorithms, market drivers, market barriers, and unmet medical needs to curate the best of the opportunities and assesses the underlying potential of the Acute Bacterial Skin and Skin Structure Infections market.
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Key highlights from the Acute Bacterial Skin and Skin Structure Infections Market Report:
According to DelveInsight, the Acute Bacterial Skin and Skin-Structure Infection (ABSSSI) market is projected to grow at a steady compound annual growth rate (CAGR) by 2034. The epidemiology of ABSSSI is set to increase due to factors such as antibiotic resistance, an aging population, and a rise in invasive medical procedures, all contributing to a higher incidence and prevalence of these infections.
While ABSSSI affects both men and women, men are typically more impacted due to factors like occupational exposure, lifestyle differences, and hormonal influences. However, the exact reasons can vary based on individual risk factors and environmental conditions. ABSSSI can occur at any age, but older adults are particularly vulnerable due to age-related skin changes, underlying health conditions, and weakened immune systems, which make them more prone to bacterial infections and complications. Younger individuals, particularly those with compromised immune systems or pre-existing medical conditions, are also at risk.
In July 2021, the U.S. Food and Drug Administration (FDA) approved AbbVie’s DALVANCE (dalbavancin) for the treatment of ABSSSI in pediatric patients, including those from birth.
The market dynamics for ABSSSI are expected to shift with the introduction of new treatment options, evolving regulatory policies, and changes in healthcare spending priorities, which could lead to increased competition among pharmaceutical companies and improved patient outcomes.
The highest rate of MRSA hospitalization was among the elderly—360.8 MRSA stays per 100,000 patients over 65 years of age which was more than three times higher for any other age group, 114.7 stays for infants, 19.2 for 1- to 17-year-olds, 58.1 for 18- to 44-year-olds, and 111.5 for 45- to 64-year-olds per 100,000.
As per secondary analysis, ABSSSI accounted for almost 870,000 hospital admissions in the United States in 2004 which represents an increase of almost 30% in the incidence of this diagnosis over a 4-year period.
Among nearly 5 million adult ABSSSI hospital admission, with admissions increasing 17.3% from 2005-2011. ABSSSI patients were primarily male (50.8%), white (60.3%), mean age 55.7 years.
According to DelveInsight’s analysis, the incidence of ABSSSI Infection is higher in men than women.
As per analysis, the microorganisms isolated most frequently from SSTIs were Staphylococcus aureus (29.2%), Pseudomonas aeruginosa (11.9%), E. coli (8.9%) and Enterococcus faecalis (7.4%).
Acute Bacterial Skin and Skin Structure Infections Overview
Acute bacterial skin and skin structure infections (ABSSSI) are a significant medical concern, presenting with a range of symptoms and potentially serious complications if not treated promptly. These infections can affect the skin and deeper structures such as subcutaneous tissues, fascia, and muscles. Understanding the causes, signs, symptoms, diagnosis, and treatment options is crucial for effective management and patient care.
Acute bacterial skin and skin structure infections (ABSSSI) encompass various infections that affect the skin and its underlying structures. They range from mild infections to severe conditions that can lead to systemic illness. Common examples include cellulitis, abscesses, and complicated skin and soft tissue infections (SSTIs). ABSSSI are often characterized by rapid onset and may require prompt medical intervention to prevent complications.
ABSSSI Causes
ABSSSI are primarily caused by bacterial pathogens. The most common bacteria responsible for these infections include:
– Staphylococcus aureus: This includes methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA). MRSA is particularly concerning due to its resistance to commonly used antibiotics.
– Streptococcus species: These bacteria, including Group A Streptococcus (GAS), can cause conditions such as cellulitis and necrotizing fasciitis.
– Gram-negative bacteria: Although less common, Gram-negative bacteria can also cause skin infections, especially in immunocompromised individuals.
– Anaerobic bacteria: These are involved in infections that may occur following trauma or surgical procedures, leading to abscess formation.
Factors contributing to the development of ABSSSI include:
– Skin injuries: Cuts, bites, and abrasions can provide an entry point for bacteria.
– Chronic conditions: Diabetes, vascular disease, and immunosuppression increase susceptibility to infections.
– Poor hygiene: Inadequate hygiene practices can facilitate bacterial growth and infection.
– Obesity: Excessive weight can lead to increased skin folds, which may trap moisture and bacteria, increasing the risk of infection.
ABSSSI Signs and Symptoms
The clinical presentation of ABSSSI can vary depending on the type and severity of the infection. Common signs and symptoms include:
– Redness: The affected area often becomes red and inflamed due to increased blood flow and immune response.
– Swelling: Edema or swelling occurs as a result of fluid accumulation and inflammatory response.
– Pain: Pain and tenderness are common, often exacerbated by movement or touch.
– Heat: The infected area may feel warm to the touch, reflecting increased blood flow and inflammation.
– Fever: Systemic symptoms such as fever may develop, especially in more severe cases or when the infection is spreading.
– Pus or discharge: Abscesses may produce pus, which can be yellow or greenish in color and may have an unpleasant odor.
– Lymphadenopathy: Swelling of nearby lymph nodes can occur, indicating that the infection is affecting the regional lymphatic system.
In severe cases, symptoms may include systemic signs of infection such as chills, fatigue, and malaise. Rapid progression of symptoms may suggest more serious conditions like necrotizing fasciitis.
ABSSSI Diagnosis
Diagnosing ABSSSI involves a combination of clinical evaluation and diagnostic testing:
– Clinical Examination: A thorough physical examination is crucial for assessing the extent and severity of the infection. The healthcare provider will evaluate the appearance of the skin, the presence of systemic symptoms, and any potential underlying conditions.
– Microbiological Testing: Obtaining a sample of the infected tissue or fluid (e.g., pus) can help identify the causative bacteria. Techniques include:
– Culture and Sensitivity: Culturing the bacteria to determine the specific pathogen and its antibiotic sensitivity.
– Gram Staining: Provides preliminary information about the type of bacteria.
– Imaging: In cases of deep or complicated infections, imaging studies such as ultrasound, CT scans, or MRI may be used to assess the extent of the infection and identify any abscesses or fluid collections.
– Blood Tests: Blood tests may be performed to assess for signs of systemic infection, such as elevated white blood cell count, and to evaluate the overall health of the patient.
ABSSSI Treatment Options
The management of ABSSSI depends on the severity of the infection and the specific bacterial pathogen involved. Treatment options include:
– Antibiotic Therapy: The cornerstone of treatment is antibiotic therapy tailored to the specific bacteria identified. Commonly used antibiotics include:
– Penicillins and Cephalosporins: Effective against many Gram-positive bacteria, including MSSA.
– Clindamycin: Often used for infections caused by Streptococcus or Staphylococcus.
– Vancomycin: Used for MRSA infections.
– Trimethoprim-Sulfamethoxazole (TMP-SMX): Effective against MRSA.
– Doxycycline: Another option for MRSA and other bacteria.
– Surgical Intervention: In cases involving abscesses or necrotizing fasciitis, surgical drainage or debridement may be necessary to remove infected tissue and facilitate healing.
– Supportive Care: Measures such as elevation of the affected limb, pain management, and fluid intake can support recovery and comfort.
– Management of Underlying Conditions: Addressing any underlying health issues, such as diabetes or vascular disease, is crucial for preventing recurrence and promoting healing.
– Hygiene and Wound Care: Proper wound care and hygiene practices are essential to prevent the spread of infection and promote healing.
Acute bacterial skin and skin structure infections (ABSSSI) pose a significant health challenge, requiring timely and effective intervention to prevent complications. Understanding the causes, recognizing the signs and symptoms, and employing appropriate diagnostic and treatment strategies are essential for optimal patient outcomes. Continued advancements in diagnostic techniques and treatment options are improving the management of these infections, contributing to better patient care and recovery.
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Acute Bacterial Skin and Skin Structure Infections Epidemiological Insights
As per Delvelnsight’s analysis, the total acute bacterial skin and skin structure infections Incident cases in 2017 in 7MM were found to be approximately 7,259,000, out of which the highest incident cases of this disease were observed in the United States.
Acute Bacterial Skin and Skin Structure Infections Treatment Market
Management of an ABSSSI is based on a multidisciplinary approach. The first step of management of an ABSSSI is the evaluation of hemodynamic state. For hemodynamically unstable patients, resuscitation and appropriate antimicrobial coverage should begin immediately. Eradication of the causative organism, alleviation of signs and symptoms, avoidance of complications and preventing recurrences are the main goals of ABSSSI therapy. Treatment for ABSSSI usually includes an antimicrobial therapy, surgical drainage, and antibiotic therapy. The therapeutic approaches favored in treating skin infections include adjunctive therapies, early and appropriate empiric antibiotic therapy, wound culture with susceptibility testing and surgical drainage and debridement. Adjunctive therapies comprise daily dressing changes, use of topical solutions including non-specific antimicrobial drugs, hyperbaric oxygen treatments, debridement, and surgical interventions planned at the initiation of treatment.
Promising Therapies in the Acute Bacterial Skin and Skin Structure Infections Pipeline
Sivextro
Nuzyra
Baxdela
Dalbavancin
Orbactiv
And others
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Leading Companies Working in the Acute Bacterial Skin and Skin Structure Infections Market
Cubist Pharmaceutical
Paratek Pharmaceutical
Menarini Group/ Melinta Therapeutics
Durata Therapeutics
The Medicine Company
To understand key companies related to the ABSSSI Market, get a snapshot of the Acute Bacterial Skin and Skin Structure Infections Regulatory and Patent Analysis @ https://www.delveinsight.com/report-store/acute-bacterial-skin-and-skin-structure-infections-market
Scope of the Acute Bacterial Skin and Skin Structure Infections Market Report
Study Period: 2020–2034
Coverage: 7MM [The United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), Japan]
Key Acute Bacterial Skin and Skin Structure Infections Companies: Cubist Pharmaceutical, Paratek Pharmaceutical, Menarini Group/ Melinta Therapeutics, Durata Therapeutics, The Medicine Company, and others
Key Acute Bacterial Skin and Skin Structure Infections Pipeline Therapies: Sivextro, Nuzyra, Baxdela, Dalbavancin, Orbactiv, and others
Therapeutic Assessment: Acute Bacterial Skin and Skin Structure Infections current marketed and emerging therapies
Acute Bacterial Skin and Skin Structure Infections Market Dynamics: Acute Bacterial Skin and Skin Structure Infections market drivers and barriers
Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter’s five forces, BCG Matrix, Market entry strategies
Unmet Needs, KOL’s views, Analyst’s views, Acute Bacterial Skin and Skin Structure Infections Market Access and Reimbursement
Table of Contents
1. Acute Bacterial Skin and Skin Structure Infections Market Key Insights
2. Acute Bacterial Skin and Skin Structure Infections Market Report Introduction
3. Acute Bacterial Skin and Skin Structure Infections Market Overview at a Glance
4. Acute Bacterial Skin and Skin Structure Infections Market Executive Summary
5. Disease Background and Overview
6. Acute Bacterial Skin and Skin Structure Infections Treatment and Management
7. Acute Bacterial Skin and Skin Structure Infections Epidemiology and Patient Population
8. Patient Journey
9. Acute Bacterial Skin and Skin Structure Infections Emerging Drugs
10. 7MM Acute Bacterial Skin and Skin Structure Infections Market Analysis
11. Acute Bacterial Skin and Skin Structure Infections Market Outlook
12. Potential of Current and Emerging Therapies
13. KOL Views
14. Acute Bacterial Skin and Skin Structure Infections Market Drivers
15. Acute Bacterial Skin and Skin Structure Infections Market Barriers
16. Unmet Needs
17. SWOT Analysis
18. Appendix
19. DelveInsight Capabilities
20. Disclaimer
21. About DelveInsight
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