DelveInsight’s, “C-MET Non-Small Cell Lung Cancer (C-MET+ NSCLC) Pipeline Insight 2025” report provides comprehensive insights about 20+ companies and 20+ pipeline drugs in C-MET Non-Small Cell Lung Cancer pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Explore the comprehensive insights by DelveInsight and stay ahead in understanding the c-MET-NSCLC Treatment Landscape. Click here to read more @ c-MET-NSCLC Pipeline Outlook

Key Takeaways from the c-MET-NSCLC Pipeline Report

• In March 2025, Merus N.V announced a phase 1/2 open-label multicenter study will be performed with an initial dose escalation part to determine the MTD and/or the RP2D of MCLA-129 in monotherapy or in combination in patients with NSCLC, HNSCC, GC/GEJ, ESCC, or other solid tumors and who are treatment naïve or have progressed after receiving prior therapy for advanced/metastatic disease.
• In March 2025, AbbVie conducted a phase 3 Open-Label, Randomized, Controlled, Global Study of Telisotuzumab Vedotin (ABBV-399) Versus Docetaxel in Subjects With Previously Treated c-Met Overexpressing, EGFR Wildtype, Locally Advanced/Metastatic Non-Squamous Non-Small Cell Lung Cancer.
• In March 2025, Betta Pharmaceuticals Co., Ltd. organized a phase I/II clinical study of MCLA-129 as monotherapy in patients with advanced solid tumors to evaluate the safety, pharmacokinetic characteristics and antitumor activity of MCLA-129.
• In March 2025, Beijing Pearl Biotechnology Limited Liability Company conducted a phase II, open-label, multicenter and multi-cohorts study of PLB1001 administered orally twice daily to locally advanced/metastatic NSCLC patients with c-Met dysregulation.
• In January 2025:- AbbVie conducted a Phase 3 Open-Label, Randomized, Controlled, Global Study of Telisotuzumab Vedotin (ABBV-399) Versus Docetaxel in Subjects With Previously Treated c-Met Overexpressing, EGFR Wildtype, Locally Advanced/Metastatic Non-Squamous Non-Small Cell Lung Cancer.
• DelveInsight’s c-MET-NSCLC pipeline report depicts a robust space with 20+ active players working to develop 20+ pipeline therapies for c-MET-NSCLC treatment.
• The leading c-MET-NSCLC Companies such as AbbVie, Janssen Research & Development, Beijing Pearl Biotechnology Limited Liability Company, Novartis, and others.
• Promising C-MET NSCLC Therapies such as Glumetinib, Tepotinib, INC280, APL-101 Oral Capsules, MCLA-129, Osimertinib, and others.

Stay informed about the cutting-edge advancements in c-MET NSCLC treatments. Download for updates and be a part of the revolution in cancer care @ c-MET NSCLC Clinical Trials Assessment

c-MET NSCLC Emerging Drugs Profile

• JNJ-61186372: Janssen Research & Development, LLC

JNJ-6372 is an EGFR-MET bispecific antibody with immune cell-directing activity that targets activating and resistant EGFR and MET mutations and amplifications. The production and development of the antibody followed Janssen’s licensing agreement with Genmab for use of its DuoBody technology platform. According to the company, JNJ-6372 is a novel bispecific antibody that has the potential to benefit patients with Exon 20 mutation insertions who often do not respond to currently available oral EGFR-targeted or immune checkpoint inhibitor therapies.

• PLB1001 – Beijing Pearl Biotechnology Limited Liability Company

PLB1001 is an orally bioavailable inhibitor of the proto-oncogene c-Met (hepatocyte growth factor receptor; HGFR) with potential antineoplastic activity. Upon administration, PLB1001 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis.

Learn more about c-MET NSCLC Drugs opportunities in our groundbreaking c-MET NSCLC Research and development projects @ c-MET NSCLC Unmet Needs

c-MET NSCLC Companies

AbbVie, Janssen Research & Development, Beijing Pearl Biotechnology Limited Liability Company, Novartis, and others.

C-MET Non-Small Cell Lung Cancer (C-MET+ NSCLC) pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Oral
• Intramuscular
• Intratumoral
• Intravenous
• Molecule Type

c-MET NSCLC Products have been categorized under various Molecule types such as

• Gene therapies
• Bispecific antibodies
• Immunotherapies
• Monoclonal antibodies
• Small molecules
• Product Type

Discover the latest advancements in c-MET NSCLC treatment by visiting our website. Stay informed about how we’re transforming the future of oncology @ c-MET NSCLC Market Drivers and Barriers, and Future Perspectives

Scope of the c-MET NSCLC Pipeline Report

• Coverage- Global
• c-MET NSCLC Companies- AbbVie, Janssen Research & Development, Beijing Pearl Biotechnology Limited Liability Company, Novartis, and others.
• C-MET NSCLC Therapies- Glumetinib, Tepotinib, INC280, APL-101 Oral Capsules, MCLA-129, Osimertinib, and others.
• c-MET NSCLC Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
• c-MET NSCLC Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III

For a detailed overview of our latest research findings and future plans, read the full details of c-MET NSCLC Pipeline on our website @ c-MET NSCLC Emerging Drugs and Companies

Table of Content

1. Introduction
2. Executive Summary
3. C-MET Non-Small Cell Lung Cancer (C-MET+ NSCLC): Overview
4. Pipeline Therapeutics
5. Therapeutic Assessment
6. C-MET Non-Small Cell Lung Cancer (C-MET+ NSCLC) – DelveInsight’s Analytical Perspective
7. In-depth Commercial Assessment
8. C-MET Non-Small Cell Lung Cancer (C-MET+ NSCLC) Collaboration Deals
9. Mid Stage Products (Phase II)
10. Telisotuzumab: AbbVie
11. PLB1001: Beijing Pearl Biotechnology Limited Liability Company
12. Drug profiles in the detailed report…..
13. Early Stage Products (Phase I)
14. JNJ-61186372: Janssen Research & Development, LLC
15. Drug profiles in the detailed report…..
16. Pre-clinical and Discovery Stage Products
17. Drug profiles in the detailed report…..
18. Inactive Products
19. C-MET Non-Small Cell Lung Cancer (C-MET+ NSCLC) Key Companies
20. C-MET Non-Small Cell Lung Cancer (C-MET+ NSCLC) Key Products
21. C-MET Non-Small Cell Lung Cancer (C-MET+ NSCLC)- Unmet Needs
22. C-MET Non-Small Cell Lung Cancer (C-MET+ NSCLC)- Market Drivers and Barriers
23. C-MET Non-Small Cell Lung Cancer (C-MET+ NSCLC)- Future Perspectives and Conclusion
24. C-MET Non-Small Cell Lung Cancer (C-MET+ NSCLC) Analyst Views
25. C-MET Non-Small Cell Lung Cancer (C-MET+ NSCLC) Key Companies
26. Appendix

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