The Malignant Pleural Effusion Market is projected to experience steady growth at a decent CAGR through 2034 The malignant pleural effusion landscape is currently characterized by the absence of approved pharmacological interventions, with traditional drainage procedures dominating treatment approaches. This creates significant opportunities for pharmaceutical innovators to address unmet needs in this oncological complication which affects thousands of cancer patients worldwide. Key companies advancing therapeutic solutions in this area include RS Oncology, Genelux Corporation, and Candel Therapeutics, among others, with some promising candidates progressing through various stages of clinical development.
DelveInsight’s “Malignant Pleural Effusion Market Insight, Epidemiology and Market Forecast 2034“ report provides a detailed analysis of market trends, epidemiological patterns, and therapeutic development across the 7MM. The United States represents the largest segment of the malignant pleural effusion market, accounting for approximately 38% of incident cases within the analyzed regions. Among European countries, Among European countries, Germany has the highest proportion of diagnosed cases, while Spain has the lowest share of diagnosed cases.
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Among total malignant pleural effusion incident cases in the US, approximately 75% receive a formal diagnosis, while 25% remain undetected. When analyzed by tumor type, lung cancer leads to the highest incidence of malignant pleural effusion, responsible for around 30% of total cases attributed to this cancer type in 2023 across the 7MM.
The report also examines the current and emerging malignant pleural effusion treatment landscape. At present, the market lacks approved pharmacological interventions specifically targeting this condition, with drainage procedures considered the standard of care across treatment centers.
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Malignant pleural effusion occurs when fluid containing cancer cells accumulates between the chest wall and the lung, resulting in symptoms such as difficulty breathing and chest discomfort. Current diagnostic approaches include cytological examination of fluid samples, histological assessment of tissue biopsies, and advanced imaging techniques like ultrasound, computed tomography, PET scans, and thoracoscopy.
Current treatment approaches focus primarily on symptom management rather than targeted modification of the disease. Therapeutic strategies usually involve conservative methods including repeated thoracentesis, pleurodesis, or the placement of indwelling pleural catheters. Additional interventions may include chemotherapy, radiation therapy, or the direct administration of medication to the pleural space, with sclerosing agents sometimes used in recurrent cases to induce pleural fibrosis and prevent fluid reaccumulation.
In early March 2025, the American Society of Clinical Oncology (ASCO) released updated guidelines for the treatment of malignant pleural mesothelioma. These updated guidelines emphasize a more nuanced approach to surgery, integration of immunotherapy, importance of genetic testing, and refined pathologic insights
Although the therapeutic pipeline for malignant pleural effusion is relatively limited, there have been some promising advancements. In September 2024, the U.S. FDA approved KEYTRUDA (Merck) in combination with pemetrexed and platinum chemotherapy for the first-line treatment of adult patients with unresectable advanced or metastatic malignant pleural mesothelioma. Additionally, RS Oncology launched a Phase II dose expansion in the MITOPE study for RSO-021 in February 2024. Other companies with potential interest in this therapeutic area include Genelux Corporation and Candel Therapeutics. The scarcity in the therapeutic pipeline offers substantial opportunities for pharmaceutical companies willing to invest in this area.
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DelveInsight’s report underscores that the limited number of companies engaging in this therapeutic area could significantly impact future market dynamics. RS Oncology’s progress through clinical trials may attract interest from larger pharmaceutical companies, potentially transforming the malignant pleural effusion therapeutic landscape in the coming years. The report also highlights that effectively addressing this condition requires a balance between providing symptomatic relief and implementing targeted approaches to manage the underlying malignancy, presenting both challenges and opportunities for stakeholders in this evolving treatment space.
Table of Contents
1
Key Insights
2
Report Introduction
3
Malignant Pleural Effusion Market Overview at a Glance
4
Executive Summary of Malignant Pleural Effusion
5
Epidemiology and Market Methodology
6
Disease Background and Overview
7
Malignant Pleural Effusion Diagnosis
8
Malignant Pleural Effusion Treatment
9
Conclusion
10
Malignant Pleural Effusion Epidemiology and Patient Population
11
Malignant Pleural Effusion Patient Journey
12
Key Endpoints in Malignant Pleural Effusion Clinical Trials
13
Malignant Pleural Effusion Emerging Therapies
14
Malignant Pleural Effusion: 7 Major Market Analysis
15
KOL Views
16
SWOT Analysis
17
Malignant Pleural Effusion Unmet Needs
18
Appendix
19
DelveInsight Capabilities
20
Disclaimer
21
About DelveInsight
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Malignant Pleural Effusion Pipeline Insights
Malignant Pleural Effusion Pipeline Insight provides comprehensive insights about the Malignant Pleural Effusion pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the Malignant Pleural Effusion companies, including LIPAC Oncology, RS Oncology, Clover Biopharmaceuticals, Gongwin Biopharm Holdings, Merk, and Simcere Pharmaceutical Group among others.
DelveInsight is a leading market research and consulting firm specializing in disease-specific insights and therapeutic market analysis. Their reports integrate real-world data, clinical trial findings, and expert interviews to deliver comprehensive industry intelligence.
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