DelveInsight’s “Chronic Lymphocytic Leukemia Market Insights, Epidemiology and Market Forecast – 2034” report delivers an in-depth understanding of Chronic Lymphocytic Leukemia (CLL), historical and forecasted epidemiology as well as the Chronic Lymphocytic Leukemia (CLL) market trends in the United States, EU4 (Germany, Spain, Italy, and France) and the United Kingdom, and Japan.
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Key Takeaways from the Chronic Lymphocytic Leukemia Market Report
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Chronic Lymphocytic Leukemia Epidemiology Segmentation in the 7MM
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Chronic Lymphocytic Leukemia Marketed Drugs
BREYANZI (lisocabtagene maraleucel; liso-cel) is a CD19-directed chimeric antigen receptor (CAR) T-cell therapy developed by Bristol Myers Squibb.
In March 2024, Bristol Myers Squibb received accelerated FDA approval for BREYANZI for adult patients with relapsed or refractory CLL /SLL who’ve had at least two prior lines of therapy, including a BTK inhibitor and a BCL-2 inhibitor. BREYANZI has shown a consistent safety profile across clinical trials, with a response rate of 95.7% and a median duration of response not reached, with 77.1% of responders still in remission at 18 months.
IMBRUVICA (Ibrutinib) by AbbVie and Johnson & Johnson Innovative Medicine was approved by the US FDA in April 2020 in combination with rituximab for the initial treatment of adult patients with CLL/SLL. IMBRUVICA is the only Bruton’s tyrosine kinase inhibitor (BTKi) approved with an oral suspension formulation, providing additional flexibility for patients who may have difficulty swallowing tablets or capsules. This flexibility is particularly important for patients with CLL or Waldenström’s macroglobulinemia (WM).
Chronic Lymphocytic Leukemia Emerging Drugs
Nemtabrutinib is an investigational reversible, non-covalent BTK inhibitor that is being studied for the suppression of oncogenic B-cell receptor signaling with activity against wild-type BTK and BTK pathway mutants. Nemtabrutinib was acquired as part of the acquisition of ArQule. Currently, the company is conducting a Phase III (NCT05624554) clinical trial of nemtabrutinib to compare the efficacy and safety of nemtabrutinib versus chemoimmunotherapy for previously untreated CLL/SLL without TP53 aberrations.
Lisaftoclax is an orally active, highly selective small molecule antagonist of BCL-2. APG-2575 induces cellular apoptosis through selective disruption of the interaction of anti-apoptotic protein BCL-2 with pro-apoptotic proteins such as BIM. The drug is in development as a single agent or as a component of combination therapy in patients with CLL/SLL. Lisaftoclax has been granted ODD by the US FDA for the treatment of CLL.
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Chronic Lymphocytic Leukemia Therapeutics Market
This section focuses on the uptake rate of potential drugs expected to be launched in the market during 2024–2034, which depends on the competitive landscape, safety, and efficacy data along with order of entry. It is important to understand that the key players evaluating their novel therapies in the pivotal and confirmatory trials should remain vigilant when selecting appropriate comparators to stand the greatest chance of a positive opinion from regulatory bodies, leading to approval, smooth launch, and rapid uptake.
Scope of the Chronic Lymphocytic Leukemia Market Report
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Table of Content
1. Key Insights
2. Report Introduction
3. Chronic Lymphocytic Leukemia (CLL) Market Overview at a Glance
4. Executive Summary of Chronic Lymphocytic Leukemia (CLL)
5. Key Events
6. Epidemiology and Market Methodology
7. Disease Background and Overview
8. Treatment and Management of Chronic Lymphocytic Leukemia (CLL)
9. Epidemiology and Patient Population
10. Patient Journey
11. Marketed Therapies
12. Emerging Therapies
13. Chronic Lymphocytic Leukemia (CLL) Disease: 7 Major Market Analysis
14. KOL Views
15. SWOT Analysis
16. Unmet Needs
17. Market Access and Reimbursement
18. Appendix
19. DelveInsight Capabilities
20. Disclaimer
21. About DelveInsight
About Us
DelveInsight is a leading healthcare-focused market research and consulting firm that provides clients with high-quality market intelligence and analysis to support informed business decisions. With a team of experienced industry experts and a deep understanding of the life sciences and healthcare sectors, we offer customized research solutions and insights to clients across the globe. Connect with us to get high-quality, accurate, and real-time intelligence to stay ahead of the growth curve.
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