DelveInsight’s “Liver Cirrhosis Market Insights, Epidemiology, and Market Forecast-2034″ report offers an in-depth understanding of the Liver Cirrhosis, historical and forecasted epidemiology as well as the Liver Cirrhosis market trends in the United States, EU4 (Germany, Spain, Italy, France) the United Kingdom and Japan.
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Key Takeaways from the Liver Cirrhosis Market Report
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Liver Cirrhosis Epidemiology Segmentation in the 7MM
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Liver Cirrhosis Emerging Drugs Profile
Efruxifermin (EFX), formerly AKR-001, is Akero’s lead product candidate for MASH cirrhosis. EFX is designed to offer convenient once-weekly SC dosing. The consistency and magnitude of observed effects position EFX to be a potentially best-in-class medicine if approved. EFX is currently being evaluated in Phase IIb clinical trials in patients with biopsy-confirmed NASH: the SYMMETRY study in cirrhotic patients with compensated F4 fibrosis. EFX shows the potential to be an effective treatment for patients with cirrhosis due to MASH. Currently the drug is in Phase II of clinical development for the treatment of MASH cirrhosis.
Belapectin (GR-MD-02), a galectin-3 inhibitor, has been demonstrated in preclinical models to reverse liver fibrosis and cirrhosis and in clinical studies to decrease portal hypertension and prevent its complication: the development of esophageal varices. Belapectin can potentially treat many diseases due to galectin-3’s involvement in multiple key biological pathways such as fibrosis, immune cell function and immunity, cell differentiation, cell growth, and apoptosis (cell death). The importance of galectin-3 in the fibrotic process is supported by experimental evidence. Animals with the galectin-3 gene “knocked-out” can no longer develop fibrosis in response to experimental stimuli compared to animals with an intact galectin-3 gene. The company is using galectin-3 inhibitors to treat advanced liver fibrosis and liver cirrhosis in MASH patients. They have completed two Phase I clinical studies, a Phase II clinical study in MASH patients with advanced fibrosis (NASH-FX) and a second Phase IIb clinical trial in MASH patients with compensated cirrhosis and portal hypertension (NASH-CX).
AstraZeneca’s combination therapy, zibotentan/dapagliflozin, is currently in Phase II clinical development targeting liver cirrhosis. This innovative treatment leverages the synergistic mechanisms of zibotentan, an endothelin A receptor antagonist, and dapagliflozin, a SGLT2 inhibitor marketed as Farxiga in the US and Forxiga globally. The small molecule duo is being evaluated in the ZEAL-UNLOCK study (Phase IIb) to assess its safety profile. Initiated in February 2024, this trial aims for a primary completion by January 2025. The study’s impactful results could redefine therapeutic strategies for liver cirrhosis, addressing a significant unmet medical need.
Liver Cirrhosis Market Outlook
With first approved therapy for advanced hepatic cirrhosis in 2024, the market outlook for liver cirrhosis is expected to expand. The most popular drug classes used to treat Liver Cirrhosis include antivirals, antibiotics, antifibrotics, etc. For individuals with severely decompensated cirrhosis, early antiviral therapy is crucial. Antiviral therapy for Chronic Hepatitis B’s primary objective is to reduce hepatic dysfunction and save patients from death. Interferon alpha (IFN) and nucleos (t) ide analogs are antiviral medications that are clinically used. The launch of emerging therapies, such as Belapectin/ GR-MD-02 (Galectin Therapeutics Inc.), Efruxifermin (Akero Therapeutics, Inc), Zibotentan/dapagliflozin (Astrazeneca), and others are expected to impact the market positively. The approval of these therapies could significantly impact market dynamics, although their success rates remain uncertain.
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Liver Cirrhosis Therapies and Companies
Scope of the Liver Cirrhosis Market Report
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Table of Contents
1. Liver Cirrhosis Market Report Introduction
2. Executive Summary for Liver Cirrhosis
3. SWOT analysis of Liver Cirrhosis
4. Liver Cirrhosis Patient Share (%) Overview at a Glance
5. Liver Cirrhosis Market Overview at a Glance
6. Liver Cirrhosis Disease Background and Overview
7. Liver Cirrhosis Epidemiology and Patient Population
8. Country-Specific Patient Population of Liver Cirrhosis
9. Liver Cirrhosis Current Treatment and Medical Practices
10. Liver Cirrhosis Unmet Needs
11. Liver Cirrhosis Emerging Therapies
12. Liver Cirrhosis Market Outlook
13. Country-Wise Liver Cirrhosis Market Analysis (2020–2034)
14. Liver Cirrhosis Market Access and Reimbursement of Therapies
15. Liver Cirrhosis Market Drivers
16. Liver Cirrhosis Market Barriers
17. Liver Cirrhosis Appendix
18. Liver Cirrhosis Report Methodology
19. DelveInsight Capabilities
20. Disclaimer
21. About DelveInsight
About DelveInsight
DelveInsight is a leading Healthcare Business Consultant, and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance. It also offers Healthcare Consulting Services, which benefits in market analysis to accelerate the business growth and overcome challenges with a practical approach.
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