DelveInsight’s “Netherton Syndrome Market Insights, Epidemiology, and Market Forecast-2032″ report offers an in-depth understanding of the Netherton Syndrome, historical and forecasted epidemiology as well as the Netherton Syndrome market trends in the United States, EU4 (Germany, Spain, Italy, France) the United Kingdom and Japan.

 

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Some of the key facts of the Netherton Syndrome Market Report

• In 2022, the total Netherton syndrome Diagnosed Prevalent Cases were estimated to be approximately 3,454 cases in the 7MM. These cases are projected to increase during the forecast period.
• In 2022, among the 7MM, the US accounted for the highest Netherton Syndrome Diagnosed Prevalent Cases, contributing nearly 49%, while Japan accounted for the least with nearly 4% of the total diagnosed prevalent cases.
• In the US, there were approximately 1,687 of Netherton syndrome diagnosed prevalent cases in 2022. These cases are expected to increase by 2032.
• In 2022, Germany ranked first among EU4 and the UK, with approximately 422 Netherton Syndrome Diagnosed Prevalent Cases, followed by France and the UK with nearly 342 and 339 cases, respectively. The total cases in EU4 and the UK are expected to increase by 2032.
• In EU4 and the UK, among the Netherton Syndrome Gender-Specific Cases, there were 685 males and 959 females in 2022. These cases are expected to increase by 2032.
• Among EU4 and the UK, Germany accounted for the highest number of females (246) affected by Netherton syndrome in 2022, followed by France, the UK, and others.
• The leading Netherton Syndrome Companies such as Lifemax Laboratories, AnaptysBio, Janssen Biotech, Northwestern University, University Hospital, and others
• Promising Netherton Syndrome Therapies such as QRX003, SPEVIGO (spesolimab/BI 655130), LM-030 (BPR277), DS-2325a, Pimecrolimus, and others

 

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Netherton Syndrome Epidemiology Segmentation in the 7MM

• Total Prevalence of Netherton Syndrome
• Prevalent Cases of Netherton Syndrome by severity
• Gender-specific Prevalence of Netherton Syndrome
• Diagnosed Cases of Episodic and Chronic Netherton Syndrome

 

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Netherton Syndrome Emerging Drugs

• QRX003: Quoin Pharmaceuticals

QRX003 is a once-daily topical lotion comprised of a broad-spectrum serine protease inhibitor formulated with the proprietary in-licensed Invisicare technology. The active ingredient in QRX003 performs the function of the missing LEKTI protein and down-regulates; however, it does not completely stop the activity of the kallikreins, leading to a more normalized skin-shedding process and the formation of a stronger and more effective skin barrier. Further, the serine protease inhibitor in QRX003 is a potent anti-inflammatory and antioxidant. QRX003 is being tested in Phase II/III clinical studies as a potential treatment for Netherton syndrome patients who are currently receiving off-label systemic therapy. Additionally, the company is developing QRX003 in other dermatological diseases, including peeling skin syndrome, SAM Syndrome, and palmoplantar keratoderma. Quoin is also investigating QRX007 in preclinical studies as a potential therapy for Netherton syndrome at Queensland University of Technology, Australia.

 

• SPEVIGO (spesolimab/BI 655130): Boehringer Ingelheim

SPEVIGO (spesolimab/BI 655130) is an interleukin-36 receptor (IL-36R) antagonist. The IL-36 pathway plays an important role in inflammation. Being a humanized antagonistic monoclonal immunoglobulin G1 (IgG1) antibody, spesolimab blocks human IL-36 receptor signaling. Further binding of spesolimab to the IL-36R prevents the subsequent activation of the IL-36R by cognate ligands (IL36 α, β, and γ) and downstream activation of pro-inflammatory pathways. Further, it is approved for treating generalized pustular psoriasis (GPP) flares in adults. The drug is undergoing a Phase II/III Netherton syndrome clinical trial.

 

Netherton Syndrome Therapies and Companies

• QRX003: Quoin Pharmaceutical
• SPEVIGO (spesolimab/BI 655130): Boehringer Ingelheim
• LM-030 (BPR277): LifeMax Laboratories/Novartis
• DS-2325a: Daiichi Sankyo
• Pimecrolimus: Children’s Hospital of Philadelphia

 

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Netherton Syndrome Drugs Market Insights

Current Netherton Syndrome Treatment approaches are limited to symptom relief or supportive care with marginal efficacy and undesirable side effects. A gentle/soft non-detergent liquid cleansing oil, preferably with an acidic pH to counteract overactive serine proteases, is recommended for daily baths and/or showers. Several classes of drugs are being used to manage Netherton syndrome, including emollients, antihistamines, topical corticosteroids, calcineurin inhibitors, calcipotriol, retinoids, immunoglobulins, antibiotics, and others. The pathogenesis basis of Netherton syndrome is well understood,with a definite link to mutations in the SPINK5 gene that have led tothe discovery of potential pathways like IL-7 and KLK inhibition. Advocacy and support groups for Netherton syndrome are spreadingawareness and providing a platform for medical experts,researchers, and patients to collaborate. IV immunoglobulin therapy in pediatrics has presented effectiveresults, and continuous research in this area can lead to thedevelopment of disease-modifying therapies. Studies have demonstrated the potential of gene therapy ingenodermatosis. Thus, developing therapies like replacementtherapy and gene therapy can cure Netherton Syndrome.

 

Netherton Syndrome Market Outlook

Netherton syndrome, a form of congenital ichthyosis, is a debilitating rare skin disorder that occurs due to a mutation in the SPINK5 gene that causes the lack of LEKTI protein that ultimately results in multiple abnormalities, including defective keratinization, severe skin barrier defects, and hair anomalies, resulting from an excessive serine protease activity. Further, patients also suffer from a pronounced predisposition to allergies, asthma, skin cancers, eczema, severe dehydration, an inability to regulate their body temperature, and chronic skin inflammation. Neonates can be severely affected by the condition, which can be fatal, and fail to gain weight and grow at the expected rate. It is usually diagnosed by examining clinical history, symptoms, and skin biopsy.

 

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Scope of the Netherton Syndrome Market Report

• Study Period: 2019-2032
• Coverage: 7MM
• Netherton Syndrome Companies: Quoin Pharmaceutical, Boehringer Ingelheim, LifeMax Laboratories, Novartis, Daiichi Sankyo, Quoin Pharmaceuticals, Children’s Hospital of Philadelphia, and others
• Netherton Syndrome Therapies: QRX003, SPEVIGO (spesolimab/BI 655130), LM-030 (BPR277), DS-2325a, Pimecrolimus, and others
• Netherton Syndrome Therapeutic Assessment: Netherton Syndrome current marketed and Netherton Syndrome emerging therapies
• Netherton Syndrome Market Dynamics: Netherton Syndrome market drivers and Netherton Syndrome market barriers
• Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter’s five forces, BCG Matrix, Market entry strategies
• Netherton Syndrome Unmet Needs, KOL’s views, Analyst’s views, Netherton Syndrome Market Access and Reimbursement

 

Table of Contents

1. Netherton Syndrome Market Report Introduction

2. Executive Summary for Netherton Syndrome

3. SWOT analysis of Netherton Syndrome

4. Netherton Syndrome Patient Share (%) Overview at a Glance

5. Netherton Syndrome Market Overview at a Glance

6. Netherton Syndrome Disease Background and Overview

7. Netherton Syndrome Epidemiology and Patient Population

8. Country-Specific Patient Population of Netherton Syndrome

9. Netherton Syndrome Current Treatment and Medical Practices

10. Netherton Syndrome Unmet Needs

11. Netherton Syndrome Emerging Therapies

12. Netherton Syndrome Market Outlook

13. Country-Wise Netherton Syndrome Market Analysis (2020–2034)

14. Netherton Syndrome Market Access and Reimbursement of Therapies

15. Netherton Syndrome Market Drivers

16. Netherton Syndrome Market Barriers

17. Netherton Syndrome Appendix

18. Netherton Syndrome Report Methodology

19. DelveInsight Capabilities

20. Disclaimer

21. About DelveInsight

 

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