DelveInsight’s “Granulomatosis with polyangiitis Market Insights, Epidemiology and Market Forecast – 2034” report delivers an in-depth understanding of the indication granulomatosis with polyangiitis, historical and forecasted epidemiology as well as the granulomatosis with polyangiitis market trends in the United States, EU4 (Germany, Spain, Italy, and France) and the United Kingdom, and Japan.

 

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Key Takeaways from the Granulomatosis with Polyangiitis Market Report

• In November 2024:- Chiba University- The goal of this clinical trial is to learn if avacopan in combination with short-term (4 weeks) reduced-dose glucocorticoid and rituximab works to treat patients with newly-onset ANCA-associated vasculitis. It will also learn about the long-term safety of avacopan.
• The prevalence of granulomatosis with polyangiitis (GPA) in the United States, estimated at 32,000 cases in 2023, is expected to rise by 2034 due to factors like an aging population, improved diagnostics, an increase in autoimmune conditions, and environmental triggers.
• In 2023, about 50% of granulomatosis with polyangiitis (GPA) cases involved the upper and lower respiratory tracts. This is due to the disease’s tendency to affect small-to-medium-sized blood vessels in these areas, leading to inflammation and granuloma formation, often resulting in chronic sinusitis, nasal obstruction, and lung nodules.
• In 2023, in the United States, a significant proportion of diagnosed prevalent cases received treatment. However, approximately 40% of these cases were classified as relapsed or refractory.
• EU4 and the UK, accounted for 55% of the total diagnosed prevalent cases of granulomatosis with polyangiitis in the year 2023.
• The leading Granulomatosis with Polyangiitis Companies such as Biogen Idec/Genentech, ChemoCentryx, InflaRx GmbH, Bristol-Myers Squibb, GlaxoSmithKlinex, and others.
• Promising Granulomatosis with Polyangiitis Therapies such as Depemokimab, Mepolizumab, SHR-1703, Benralizumab, and others.

 

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Granulomatosis with Polyangiitis Segmentation in the 7MM

• Total Prevalent Cases
• Diagnosed Prevalent Cases
• Diagnosed Prevalent Cases
• Diagnosed Prevalent Cases
• Total Treated Cases

 

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Granulomatosis with polyangiitis Marketed Drugs

• TAVNEOS (avacopan): Chemocentryx/Amgen

TAVNEOS (avacopan), approved by the FDA as an adjunctive treatment for adults with severe active ANCA-associated vasculitis, is a first-in-class, orally administered small molecule that employs a novel, highly targeted mode of action in complement-driven autoimmune and inflammatory diseases.

 

• RITUXAN (rituximab): Genentech/Biogen

Rituximab is a monoclonal antibody that targets the CD20 antigen expressed on the surface of pre-B and mature B-lymphocytes. Upon binding to CD20, rituximab mediates B-cell lysis. Possible mechanisms of cell lysis include complement dependent cytotoxicity (CDC) and antibody dependent cell mediated cytotoxicity (ADCC). B cells are believed to play a role in the pathogenesis of rheumatoid arthritis (RA) and associated chronic synovitis.

 

Granulomatosis with polyangiitis Market Outlook

The market size for granulomatosis with polyangiitis in the seven major markets is projected to experience significant growth from 2024, driven by a notable increase in prevalent cases and the necessity for innovative therapies that can provide more effective, long-term relief for the thousands of patients affected by granulomatosis with polyangiitis.

 

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Granulomatosis with Polyangiitis Treatment Market

The treatment approach for granulomatosis with polyangiitis (GPA) involves two main phases: induction and maintenance. Initially, induction therapy aims to rapidly control inflammation and halt disease progression, typically using a combination of rituximab or cyclophosphamide with glucocorticoids. For less severe cases, methotrexate may be used as an alternative. Once remission is achieved, the focus shifts to maintenance therapy to prevent relapse. Azathioprine or methotrexate is commonly employed during this phase, often with lower doses of glucocorticoids. The treatment strategy is tailored to the individual’s disease severity, response to therapy, and potential side effects, ensuring long-term disease control with minimized toxicity.

 

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Scope of the Granulomatosis with Polyangiitis Market Report

• Coverage- 7MM
• Granulomatosis with Polyangiitis Companies- Biogen Idec/Genentech, ChemoCentryx, InflaRx GmbH, Bristol-Myers Squibb, GlaxoSmithKlinex, and others.
• Granulomatosis with Polyangiitis Therapies- Depemokimab, Mepolizumab, SHR-1703, Benralizumab, and others.
• Granulomatosis with Polyangiitis Competitive Intelligence Analysis: SWOT analysis and Market entry strategies
• Granulomatosis with Polyangiitis Unmet Needs, KOL’s views, Analyst’s views, Granulomatosis with Polyangiitis Market Access and Reimbursement

 

Table of Content

1 Key Insights

2 Report Introduction

3 Granulomatosis with Polyangiitis Market Overview at a Glance

4 Granulomatosis with polyangiitis Methodology

5 Executive Summary

6 Disease Background and Overview

7 Granulomatosis with polyangiitis Diagnosis

8 Treatment of Granulomatosis with polyangiitis

9 Diagnostic and Treatment Guidelines for Granulomatosis with Polyangiitis

10 Conclusion

11 Granulomatosis with polyangiitis Epidemiology and Patient Population

12 Granulomatosis with polyangiitis Patient Journey

13 Granulomatosis with polyangiitis Marketed Therapies

14 Granulomatosis with polyangiitis Market Analysis

15 KOL Views

16 Granulomatosis with polyangiitis Market Barriers

17 Granulomatosis with polyangiitis Market Drivers

18 SWOT Analysis

19 Granulomatosis with polyangiitis Unmet Needs

20 Appendix

21 DelveInsight Capabilities

22 Disclaimer

23 About DelveInsight

 

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